NHS Endurance Edge
Proprietary Blend (we will offer in both liquid and capsule
form):
Ribose
Glucuronolactone
Malic Acid
Magnesium malate
Vitamin C
Citric acid
L-Citrulline
L-Taurine
The endurance athlete pre-workout formula provides a source
of ATP fuel the body needs to move forwards with ribose, a simplified
cyclic sugar used by the body as a fuels source and template
in RNA synthesis.
Ribose (see below for detailed information on
ribose) gets accessed by type II muscle tissue which runs deep
in the musculoskeletal system.
These muscle cells do not utilize creatine, however do respond
to ribose as a fuel source.
Arginine once again acts to increase blood flow to the body
by relaxing the endothelial cells of the circulatory system
which provides a lower blood pressure with increased blood
flow that moves energy in and waste products out more efficiently.
The remaining materials in the enduro formula provides for
the conversion of waste products generated by the athletic activity
to a form that is removable by the body.
This becomes very important as fatigue arises from the waste
by-products associated with energy production and consumption.
Furthermore, ribose and taurine have been shown in the scientific
literature to strengthen the heart muscle and regulate it’s
performance, which is crucial if one is to continue to push the
limits of physical activity in athletic performance
Ribose, is a naturally occurring sugar used by every cell of
the body. It's an essential compound in energy metabolism, serving
as a building block for adenosine triphosphate (ATP)-the body's
basic energy source. D-ribose is also the carbohydrate backbone
of genetic material, DNA and RNA, certain vitamins and other
important cellular compounds.
Research has shown that ribose helps the body to maintain healthy
energy levels in the heart and muscle tissues. It maximizes energy
recovery and may also increase energy reserves. If you work out
more than three or four times per week, your body may not have
the rest time it needs between sessions for heart and muscle
energy pools to return to normal levels. Other products containing
Ribose are NHS Energizer, see link: http://www.nutritionmanufacturer.com/nhs_energizer.html
Explanation of Key Ingredients:
Citrulline is an amino acid that supports the body in optimizing
blood flow through its conversion to L-arginine and then nitric
oxide. Nitric oxide is involved in vasodilatation, and low levels
are associated with mental and physical fatigue and sexual dysfunction.
Citrulline, which is considered a non-essential amino acid
synthesized in the intestinal tract from Glutamine, converts
to Arginine in the endothelial cells. This biochemical process
involves L-Aspartate and the enzymes Argininosuccinate Synthetase
and Argininosuccinate Lyase, in the presence of ATP. Arginine
is important for Nitric Oxide production for cardiovascular health;
however, most Arginine is utilized in the liver and kidneys,
and only a fraction is available for this purpose. Since Citrulline
is a precursor to Arginine, it allows for increased and sustained
Nitric Oxide production in the endothelium for support of circulatory
function.
Oral Citrulline supplementation provides a readily available
source of Citrulline for this purpose, and some recent research
further indicates that Citrulline may be the preferred source
of cellular Arginine. In addition Citrulline also increases energy,
stimulates the immune system, and is essential for Urea Cycle
function as well.
Glucuronolactone -is a fascinating compound and appears not
only to be safe, but hepatoprotective. A pathway of interest
is the clearance of toxic metabolites and liberation of lipophillic
steroids. DGL may increase the bioavailability of an exogenous
hormone being administered, thereby increasing the direct effect
elicited.
Moreover, the compound could remove metabolites that could potentially
be hepatotoxic and may reverse prior liver damage. DGL may also
be an ergogenic aid by protecting glycogen stores and their synthesis.
Lastly, it may be joint and tendon protective benefiting the
athlete by potentially reducing risk of injury and associated
pain.
This fully referenced article should serve as an exhaustive
resource for the athlete, through scientifically-based research
and theory. I would appreciate feedback from readers that have
supplemented with the compound (especially in its pure form)
on its performance, liver, and joint benefits
Malic acid -is both derived from food sources and synthesized
in the body through the citric acid (Krebs) cycle. Its importance
to the production of energy in the body during both aerobic and
anaerobic conditions is well established. Under aerobic conditions,
the oxidation of malate to oxaloacetate provides reducing equivalents
to the mitochondria through the malate-aspartate redox shuttle.
During anaerobic conditions, where a buildup of excess of reducing
equivalents inhibits glycolysis, malic acids simultaneous reduction
to succinate and oxidation to oxaloacetate is capable of removing
the accumulating reducing equivalents. This allows malic acid
to reverse hypoxias inhibition of glycolysis and energy production.
This may allow malic acid to improve energy production in FM,
reversing the negative effect of the relative hypoxia (a shortage
of oxygen in the body).
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