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What is NO2 - plus and where does it come from?
Nitric Oxide is a free form gas that is produced in the body and
is used by the body to communicate with other cells in the body.
To produce this gas, enzymes in the body break down the amino acid
Nitric Oxide is a molecule consisting of one atom of nitrogen
and one atom of oxygen. The production of Nitric Oxide occurs when
the amino acid L-arginine is converted into L-citruline through
an enzyme group known as Nitric Oxide Synthase (NOS).
What does it do and what scientific studies give evidence
to support this?
Despite the claims of some in the supplement industry, there exists
ample scientific literature to substantiate the efficacy of Nitric
Oxide products. The following was written in May 1996 in a document
prepared for the Royal Society and Association of British Science
"Summary research papers continue to flood the scientific
journals and insights into the biological activity and potential
clinical uses of nitric oxide (NO): a gas controlling a seemingly
limitless range of functions in the body. Each revelation adds
to nitric oxide's already lengthy resume in controlling the circulation
of the blood, regulating activities of the brain, lungs, liver,
kidneys, stomach and other organs.
The molecule governs blood pressure through a recently recognized
process that contradicts textbook wisdom. It causes penile erection
by dilating blood vessels and controls the action of almost every
orifice from swallowing to defecation. The immune system uses nitric
oxide in fighting viral, bacterial and parasitic infections, and
tumors. Nitric oxide transmits messages between nerve cells and
is associated with the process of learning, memory, sleeping, feeling
pain, and, probably depression. It is a mediator in inflammation
Since the above was written in 1996, Nitric Oxide containing
products have continued to be touted by those in the medical profession,
as well as by athletes looking to add muscle to their frames.
The above quotation states that Nitric Oxide controls the circulation
of blood, transmits messages between nerve cells, and is a mediator
of inflammation and is associated with the process of feeling pain.
The popular erectile dysfunction drug sildenafil citrate (Viagra)
contains nitric oxide and is responsible for increasing blood flow
to the penis.
The fact that nitric oxide increases blood flow should make it
of interest to bodybuilders, as increased blood flow will serve
to deliver more nutrients to muscles, thus helping muscles become
larger when subject to stress. The fact that Nitric Oxide acts
to reduce inflammation should also make it of interest to bodybuilders
as it has the potential to reduce the pain associated with subjecting
muscles to extreme stress.
Nitric oxide also affects the endocrine system. It affects the
release of gonadotroptin releasing hormone, as well as the release
of adrenaline from the adrenal medulla.
Who needs it and what are some symptoms of deficiency?
Everyone REQUIRES nitric oxide to carry out key physiological
processes within the body. From a bodybuilder's perspective, nitric
oxide supplementation may prove useful in increasing growth due
to increases in blood flow to certain areas of the body. Further,
men suffering from erectile dysfunction may also find supplementing
with nitric oxide helpful.